Abstract： Objective： To observe the application value of oral administration of Radix et RhizomaRhei and external application of Natrii Sulfas combined with evidence-based nursing in nursing for severe acute pancreatitis(SAP). Methods：A total of 78 cases of SAP patients were randomly divided into two groups， 39 cases in each group. The control group was additionally given evidence- based nursing based on routine treatment， and the observation group was additionally treated with oral administration of Radix et RhizomaRhei and hot compress of Natrii Sulfas on umbilicus based on the treatment of the control group. The clinical effect in the two groups was observed；the time indexes were recorded；the infection rates and mortality rates in the two groups were compared. Results：The total effective rate was 92.31% in the observation group and 74.36% in the control group，the difference being significant(P＜0.05). After treatment，the remission time of abdominal pain and abdominal distension， the recovery time of bowel sound， the first defecation time and the hospitalization time in the observation group were obviously shorter than those in the control group， the difference being significant(P＜0.05). The infection rate was 7.69% in the observation group and 25.64% in the control group，and the mortality rate was 5.13% in the observation group and 12.82% in the control group；the infection rate in the observation group was obviously lower than that in the control group(P＜0.05)， and there was no significant difference being found in the comparison of the mortality rates between the two groups(P＞0.05). Conclusion：The application of Radix et RhizomaRhei and hot compress of Natrii Sulfas on umbilicus combined with evidence-based nursing can significantly improve clinical effect and decrease the time indexes and infection rate.