Abstract： Objective： To discuss the effect of auricular acupoint pressing with beans combined with psychological intervention on nausea，vomiting and sleep quality in senile patients after radical thyroidectomy under endoscopy. Methods： A total of 115 cases of senile patients undergoing radical thyroidectomy under endoscopy were divided into the control group and the observation group according to the random number table method，57 and 58 cases in each group respectively. The control group was given routine nursing， and the observation group was additionally given auricular acupoint pressing with beans combined with psychological intervention based on the treatment of the control group. Before and after nursing，the improvement of nausea and vomiting，the scores of pain，the negative emotions，the cognitive function，the sleep quality， the quality of life and the compliance in the two groups were compared. Results：After nursing，the incidence of nausea and vomiting in the observation group was obviously lower than that in the control group，the difference being significant(P＜0.05). Before nursing， there was no significant difference being found in the comparison of the scores of Visual Analogue Scale (VAS)，anxiety and depression in the two groups(P＞0.05). After nursing，the scores of VAS，anxiety and depression in the two groups were decreased when compared with those before nursing(P＜0.05)， and the above scores in the observation group were lower than those in the control group(P＜0.05). Before nursing，there was no significant difference being found in the comparison of the scores of Mini-Mental State Examination(MMSE)，Pittsburgh Sleep Quality Index(PSQI) and quality of life in the two groups(P＞0.05). After nursing，the scores of MMSE and quality of life in the two groups were increased when compared with those before nursing， and the scores of PSQI were decreased； the scores of MMSE， quality of life and compliance in the observation group were higher than those in the control group， and the score of PSQI was lower； differences being significant(P＜0.05). Conclusion： The therapy of auricular acupoint pressing with beans combined with psychological intervention can effectively reduce the incidence of nausea and vomiting in senile patients after radical thyroidectomy under endoscopy，relieve postoperative pain，improve their cognitive function，sleep quality and quality of life after operation，and enhance their compliance.