Abstract：Objective：To observe the clinical effect of the therapy of modified Xiao'er Zhixiao prescription combined with budesonide for bronchial asthma in children. Methods：A total of 96 cases of children with bronchial asthma were divided into the control group and the observation group according to random number table method， 48 cases in each group. The control group was treated with budesonide aerosol based on the treatment of conventional treatment， and the observation group was additionally treated with Xiao'er Zhixiao prescription based on the treatment of the control group. The clinical effect， clinical symptom remission time， and changes in the levels of inflammatory indexes such as interleukin- 4(IL- 4)， interleukin- 5(IL- 5)， tumor necrosis factor- α(TNF- α)， vascular endothelial growth factor(VEGF)， immunoglobulin E(IgE)， and human thymic stromal lymphopoietin(TSLP)， and in lung function indexes were compared in both groups. Results：Before treatment，there was no significant difference in the comparison of the inflammatory indexes and lung function indexes between the two groups(P＞0.05). After treatment，the levels of IL-4，IL-5，TNF-α，IgE，TSLP and VEGF in both groups were decreased，and the levels of all indexes in the observation group were lower than those in the control group(P＜0.05). All lung function indexes in the two groups were significantly improved when compared with those before treatment，and the recovery of lung function in the observation group was better than that in the control group(P＜ 0.05). After treatment，the remission time of cough，pant，dyspnea and wheezing in the observation group was shorter than that in the control group， the difference being significant(P＜0.05). The total effective rate was 83.33% in the observation group， higher than that of 62.50% in the control group(P＜0.05). Conclusion： The therapy of Xiao'er Zhixiao prescription combined with budesonide has significant therapeutic effect in treating children with bronchial asthma， which has the characteristics of quick effect and great curative effect.