Abstract：Objective：To observe the clinical effect of Yiqi Huazhuo prescription combined with routine western medicine for chronic kidney disease of stage Ⅲ~Ⅳ. Methods：A total of 88 cases of patients with chronic kidney disease of stage Ⅲ~Ⅳ were included in the study and were divided into the observation group and the control group according to the random number table method，45 and 43 cases in each group respectively. The control group was treated with alprostadil injection，and the observation group was additionally treated with Yiqi Huazhuo prescription based on the treatment of the control group. After treatment， the clinical effect， the Chinese medicine syndrome scores and the indexes of the kidney function in the two groups were compared. Results： The total clinical effective rate was 62.79% in the control group and 84.44% in the observation group， the difference between the two groups was statistically significant(P＜0.05). Before treatment， compared the Chinese medicine syndrome scores and the blood urea nitrogen(BUN)，serum creatinine(SCr)，24-hour urine protein ratio(Upr)，uric acid(UA) and estimated glomerular filtration rate(eGFR)，there was no significance in the difference(P＞ 0.05). After treatment，the main and secondary scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the scores in the observation group were significantly lower than those in the control group(P＜0.05)；the levels of BUN，UA，SCr and Upr in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above levels in the observation group were significantly lower than those in the control group(P＜0.05)， the level of eGFR in the two groups were significantly higher than that before treatment， and the level of eGFR in the observation group was higher than that in the control group. Conclusion：The therapy of Yiqi Huazhuo prescription combined with routine western medicine in treating patients with chronic kidney disease of stage Ⅲ ~ Ⅳ is conductive to improving curative effect，relieving clinical symptoms and improving the indexes of the kidney function.