Abstract： Objective： To observe the clinical effect of Ningmitai capsules combined with tamsulosin hydrochloride sustained-release tablets for nonbacterial type III prostatitis. Methods：A total of 100 cases of patients with nonbacterial type III prostatitis were divided into the study group and the control group according to the random number table method，50 cases in each group. The control group was treated with tamsulosin hydrochloride sustained-release tablets，and the study group was additionally given oral administration of Ningmitai capsules based on the treatment of the control group. Before and after treatment， the scores of NIH- Chronic Prostatitis Symptom Index(NIH- CPSI) and Chinese medicine syndromes in the two groups were evaluated， and the levels of prostaglandin E2(PGE2)， white blood cell count in expressed prostatic secretion (EPS- WBC) and tumor necrosis factor- α(TNF- α) in the two groups were detected. Results：Before treatment，compared the total scores of NIH- CPSI and the scores of pain， uncomfortable symptoms， voiding symptoms and quality of life between the two groups，there was no significance in the difference(P＞0.05). After treatment，the total scores of NIH-CPSI and the scores of pain，uncomfortable symptoms，voiding symptoms and quality of life in the two groups were all decreased when compared with those before treatment，and the total score of NIH-CPSI in the study group was lower than that in the control group，differences being significant(P＜0.05). After treatment，the total scores of Chinese medicine symptoms and the scores of main and secondary symptoms in the two groups were decreased when compared with those before treatment，and the above scores in the study group were lower than those in the control group，differences being significant (P＜0.05). After treatment，the levels of PGE2，EPS-WBC and TNF-α in the two groups were decreased when compared with those before treatment，and the above levels in the study group were lower than those in the control group，differences being significant(P＜0.05). Conclusion：The therapy of Ningmitai capsules combined with tamoxin hydrochloride sustainedrelease tablets can significantly improve the clinical symptoms of patients with nonbacterial type III prostatitis，and reduce the levels of PGE2，EPS-WBC and TNF-α in expressed prostatic secretion，which is worthy of clinical promotion.