Abstract： Objective： To observe the clinical effect of modified Qingre Qushi prescription combined with western medicine for chronic atrophic gastritis(CAG) complicated with intestinal metaplasia(IM) of spleen- stomach dampness- heat type. Methods：A total of 96 cases of patients with CAG complicated with IM of spleen-stomach dampness-heat type were divided into the observation group and the control group according to the random number table method， 48 cases in each group. There were two and four cases lost in the observation group and the control group. The control group was given treatment for enhance nutrition of intestinal mucosa，protection of gastric mucosa， acid suppression and anti-helicobacter pylori；the observation group was additionally treated with modified Qingre Qushi prescription based on the treatment of the control group. Both groups were treated for four weeks. The Chinese medicine syndrome scores and the grade of IM before and after treatment，and the curative effect and the negative rate of helicobacter pylori after treatment in the two groups were compared. Results： After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the decrease in the observation group was larger than that in the control group(P＜0.05). After treatment， the grade of IM in the observation group was improved when compared that before treatment(Z=12.89，P＜0.01)；there was no significant difference being found in the comparison of the grade of IM in the control group before and after treatment(Z=1.69，P＞0.05)；the grade of IM in the observation group was better than that in the control group(Z=4.88， P＜0.05). The total effective rate was 95.65% in the observation group， higher than that of 79.55% in the control group(P＜0.05). After treatment， the negative rate of helicobacter pylori was 92.00% in the observation group， higher than that of 66.67% in the control group(P＜0.05). Conclusion： The modified Qingre Qushi prescription in treating patients with CAG complicated with IM of spleen-stomach dampness-heat type is conductive to improving Chinese medicine syndrome， reducing IM and promoting radical treatment of helicobacter pylori.