Abstract：Objective：To observe the curative effect of the therapy of Xiangsha Yangwei pills combined with lansoprazole for chronic atrophic gastritis of spleen deficiency and qi stagnation type. Methods：A total of 216 patients with chronic atrophic gastritis of spleen deficiency and qi stagnation type were divided into two groups according to the random number table method，108 cases in each group. The control group was treated with lansoprazole orally，and the observation group was additionally treated with Xiangsha Yangwei pills based on the treatment of the control group. Before and after treatment，the scores of gastroscopy and Chinese medicine syndromes， the contents of interleukin- 11(IL- 11)， interleukin- 8(IL- 8) and tumor necrosis factor- α(TNF- α) in serum， malondialdehyde(MDA) and the content of prostaglandin E2(PEG2) in the two groups were observed，and the clinical effect and adverse reactions were also counted. Results：The total effective rate was 95.37% in the observation group and 86.11% in the control group，the difference being significant(P＜0.05). After treatment， the scores of gastroscopy and Chinese medicine syndromes in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above two scores in the observation group were significantly lower than those in the control group(P＜0.05). After treatment，the levels of MDA in the gastric mucosa，IL-11 and IL-8 in serum and TNF-α in the two groups were decreased when compared with those before treatment(P＜0.05)，while the contents of PEG2 were increased when compared with those before treatment(P＜0.05)； the improvement of the above indexes was more significant in the observation group than that in the control group(P＜0.05). There were four cases of nausea and vomiting occurred in the observation group and six cases in the control group；there was no significant difference between the two groups in the comparison of the incidence of adverse reactions(P＞0.05). Conclusion：The therapy of Xiangsha Yangwei pills combined with lansoprazole can significantly improve the pathological changes and clinical symptoms of patients with chronic atrophic gastritis of spleen deficiency and qi stagnation type，reduce the contents of inflammatory cytokines in the serum， and has great safety.