Abstract：Objective：To observe the clinical effect of modified Xiaobu Jianshi tang combined with celecoxib for subactue thyroiditis with qi deficiency and phlegm obstruction syndrome. Methods： A total of 80 cases of patients with subactue thyroiditis with qi deficiency and phlegm obstruction syndrome were divided into the treatment group and the control group according the random number table method，40 cases in each group. The treatment group was treated with modified Xiaobu Jianshi tang combined with celecoxib capsules，and the control group was given celecoxib capsules only. Both groups were treated for four weeks. The clinical effect in the two groups was compared. The improvement of thyroid hormone， erythrocyte sedimentation rate(ESR) and quality of life was observed. The recurrence rates during the eight-week follow-up in the two groups were compared. The incidence of adverse reactions was recorded. Results：The total effective rate was 77.50% in the control group，and 90.00% in the treatment group，the difference being significant(P＜0.05). After treatment， the levels of free thyroxine(FT4)，free triiodothyronine(FT3) and ESR in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of thyroid-stimulating hormone(TSH) were increased when compared with those before treatment(P＜0.05)；the levels of FT4，FT3 and ESR in the treatment group were lower than those in the control group(P＜0.05)；there was no significant difference being found in the comparison of the level of TSH between the two groups (P＞0.05). After treatment， the scores of Short Form 36 Health Survey(SF- 36) in the two groups were increased when compared with those before treatment(P＜0.05)；the above score in the treatment group was higher than that in the control group(P＜0.05). During the eight-week follow-up after administration，there was no recurrence in the treatment group and two cases in the control group， the recurrence rate was 6.45% in the control group， there being no significance in the difference(P＞0.05). There was no significant adverse reaction in the treatment group；in the control group，there were two cases of stomachache and one case of transaminase elevation. Conclusion： The therapy of modified Xiaobu Jianshi tang combined with celecoxib has good clinical effect in treating subactue thyroiditis with qi deficiency and phlegm obstruction syndrome，which can improve the quality of life without any adverse reactions.