Abstract：Objective：To observe the clinical effect of stomach- clearing and spleen- fortifying method for helicobacter pylori-positive chronic atrophic gastritis. Methods：A total of 60 cases of patients of stomach heat and spleen deficiency type were selected as the study objects，and were randomly divided into the control group and the treatment group，30 cases in each group. The control group was given quadruple therapy to eradicate helicobacter pylori，and the treatment group was treated with stomach-clearing and spleen-fortifying method. Both groups were given drugs for two weeks. Before and after treatment，the quality of life of patients was evaluated by Quality of Life(QOL) scale. Two weeks after drug withdrawal， helicobacter pylori was detected by 13C- urea breath test， and clinical effect was assessed by re- examination of gastroscopy. Results：After treatment，the total effective rate of clinical effect was 96.67% in the treatment group，higher than that of 76.67% in the control group，the difference being significant(P＜0.05). The scores of quality of life in the two groups were increased when compared with those before treatment，the difference being significant(P＜0.01). The score of quality of life in the treatment group was higher than that in the control group，the difference being significant(P＜0.01). Two weeks after drug withdrawal，the positive rate of helicobacter pylori was 6.67% in the treatment group and 26.67% in the control group， the difference being significant(P＜0.05). Conclusion： The application of stomach- clearing and spleenfortifying method for chronic atrophic gastritis of stomach heat and spleen deficiency type has definite curative effect，and can effectively eradicate helicobacter pylori and improve clinical symptoms and quality of life.