Abstract：Objective：To observe the clinical effect of Huayu Tongmai tang for acute cerebral infarction and its effect on neurological function and prognosis. Methods：A total of 90 cases of patients with acute cerebral infarction were divided into the control group and the observation group according to the random number table method，45 cases in each group. The control group was given routine treatment， and the observation group was additionally treated with Huayu Tongmai tang based on the treatment of the control group. After treatment for four weeks， the clinical effect in the two groups was evaluated. Before and after treatment，the changes of neurological function in the two groups were observed. After treatment for six months，the prognosis including motor function，neurological function and activity of daily living in the two groups was observed. Results： The total effective rate was 95.56% in the observation group and 80.00% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of National Institutes of Health Stroke Scale(NIHSS) and Glasgow Coma Scale(GCS) between the two groups (P＞0.05). After treatment， the scores of NIHSS and GCS in the two groups were improved when compared with those before treatment，and the scores in the observation group were better than those in the control group，differences being significant(P＜0.05). After six-month follow- up，the scores of NIHSS，Fugl-Meyer and Barthel in the observation group were better than those in the control group， differences being significant(P＜0.05). Conclusion： Huayu Tongmai tang for acute cerebral infarction can effectively improve clinical effect，relieve defect degree of neurological function and improve prognosis including motor function，neurological function and activity of daily living.