Abstract： Objective： To evaluate the effect of multi- slice spiral CT portal vein imaging on the diagnosis of Chinese medicine syndrome types in patients with cirrhosis. Methods：Sixty patients with hepatitis B cirrhosis from February 2017 to March 2019 were included in the study， and were differentiated into different Chinese medicine syndrome types. Thirty patients of qi stagnation and stasis obstruction type were classified into the qi stagnation and stasis obstruction group，and 30 patients of other Chinese medicine syndrome types were classified into the non-qi stagnation and stasis obstruction group. Multi- slice spiral CT portal vein imaging was performed in both groups to calculate the peak duration of portal vein enhancement， the difference in maximum liver density， integral value of portal vein branch， integral value of contour boundary，perfusion volume of portal vein in the region of interest，perfusion volume of hepatic artery ，and total hepatic perfusion volume in the two groups. Results：The peak duration of portal vein enhancement and the difference in maximum liver density in the qi stagnation and stasis obstruction group were larger than those in the non- qi stagnation and stasis obstruction group(P＜0.05). The integral value of portal vein branch and integral value of contour boundary in the qi stagnation and stasis obstruction group were larger than those in the non- qi stagnation and stasis obstruction group(P＜0.05). The perfusion volume of portal vein in the region of interest，perfusion volume of hepatic artery ，and total hepatic perfusion volume in the qi stagnation and stasis obstruction group were smaller than those in the non- qi stagnation and stasis obstruction group(P＜0.05). Conclusion： Multi- slice spiral CT portal vein imaging can provide the basis of syndrome differentiation for the diagnosis of Chinese medicine syndrome types in patients with cirrhosis.