参苓白术散辅助化疗对晚期结直肠癌患者生活质量的影响
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R735.3+5;R735.3+7

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Effect of Shenling Baizhu Powder Assisting Chemotherapy on Quality of Life of Patients with Advanced Colorectal Cancer
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    摘要:

    目的:观察参苓白术散辅助化疗对晚期结直肠癌患者生活质量的影响。方法:将 98 例晚期结直肠癌患者随机分为2 组,对照组 49 例给予常规化疗治疗,观察组 49 例给予参苓白术散联合常规化疗治疗。观察比较 2 组治疗前后中医症状评分,肿瘤标志物癌胚抗原 (CEA)、糖类抗原 (CA199) 水平及各项生活质量 (躯体、情感、家庭、功能) 评分;并比较 2 组总体临床疗效及化疗不良反应。结果:缓解率观察组为 77.55%,对照组为 51.02%,2 组比较,差异有统计学意义 (P<0.05)。治疗后,2 组中医症状腹痛腹胀、便溏评分均较治疗前降低 (P<0.05),且观察组两项评分均低于对照组 (P<0.05)。治疗后,2 组血清 CEA、CA199 水平均较治疗前明显降低 (P<0.05),且观察组两项指标明显低于对照组 (P<0.05)。治疗后,2 组患者躯体、情感、家庭、功能生活质量评分均较治疗前升高 (P<0.05),且观察组各项评分均高于对照组 (P<0.05)。观察组恶心呕吐、食欲减退、肝肾损害、骨髓抑制不良反应率均低于对照组,差异有统计学意义(P<0.05)。结论:化疗联合参苓白术散治疗结直肠癌,可明显降低肿瘤标志物水平,改善临床症状,提高患者生活质量,有增效减毒作用。

    Abstract:

    Abstract: Objective: To observe the effect of Shenling Baizhu powder assisting chemotherapy on quality of life of patients with advanced colorectal cancer. Methods:A total of 98 cases of patients with advanced colorectal cancer were randomly divided into two groups,49 cases in each group. The control group was given routine chemotherapy,and the observation group was additionally given Shenling Baizhu powder based on the treatment of the control group. Before and after treatment,Chinese medicine symptom scores,the levels of tumor markers,namely,carcinoembryonic antigen(CEA) and carbohydrate antigen 199(CA199),and each score of quality of life including body,emotion,family,and function were observed in the two groups. The total clinical effect and the adverse reactions induced by chemotherapy were compared between the two groups. Results: The rate of complete remission and partial remission was 77.55% in the observation group,and 51.02% in the control group,the difference being significant(P<0.05). After treatment,the scores of Chinese medicine symptoms including abdominal pain and abdominal distension,and sloppy stool in the two groups were decreased when compared with those before treatment(P<0.05);the two scores in the observation group were lower than those in the control group(P<0.05). After treatment, the levels of CEA and CA199 in serum in the two groups were significantly decreased when compared with those before treatment(P<0.05); the two indexes in the observation group were significantly lower than those in the control group(P<0.05). After treatment, the scores of quality of life including body, emotion, family, and function in the two groups were increased when compared with those before treatment(P<0.05); each score in the observation group was higher than that in the control group(P<0.05). The incidence of nausea,vomiting, poor appetite,damage of the liver and the kidney and myelosuppression adverse reactions in the observation group was lower than that in the control group,the difference being significant(P<0.05). Conclusion:In the treatment of colorectal cancer,the therapy of chemotherapy combined with Shenling Baizhu powder can significantly reduce the levels of tumor markers,and improve clinical symptoms and quality of life,with the effect of enhancing efficacy and reducing toxicity.

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梁超,黄劼,刘超.参苓白术散辅助化疗对晚期结直肠癌患者生活质量的影响[J].新中医,2020,52(22):46-49

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  • 在线发布日期: 2020-11-27
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