Abstract：Premature ovarian insufficiency(POI) is a common disease in gynecology. In recent years，its incidence has showed an increasing trend. By concluding and summarizing its Chinese medicine treatment in clinic， it is found that in Chinese medicine，the disease is due to insufficient kidney essence，and the treatment is to tonify the kidney and at the same time differentiate the syndromes according to the disease condition， and to regulate the heart， liver and spleen. Chinese medicine treatment has few adverse reactions，definite curative effect and great advantages in treating POI.