Objective： To study the distribution rule of constitution of Chinese medicine in senile patients with osteoporosis and the relationship between constitution type and syndrome differentiation type.Methods：A total of 550 cases of senile patients with osteoporosis were selected as subjects.The self-designed Questionnaire of Chinese Medicine Syndrome was used for Chinese medicine syndrome differentiation，and their constitution were classified according to Classification and Determination of Constitution in Traditional Chinese Medicine.The distribution of constitution type and syndrome type as well as the distribution of constitution of patients at different ages(50～60 years old，61～70 years old，71～80 years old)and at different disease courses(less than 5 years，5～8 years，over 8 years)，and the correlation between constitution and syndrome type were analyzed.Results：Chinese medicine constitution types in them were divided into nine types： yang deficiency， neutral， blood stasis， qi deficiency， phlegm dampness， qi stagnation， dampness heat， yin deficiency and special endowment.Among them，the yin-deficiency constitution accounted for the most(28.7%)and the qi-stagnation constitution and the special-endowment constitution the least(0.9%).There was no significant difference in the comparison of the statistical analysis on the distribution of Chinese medicine constitution type at different ages(P＞0.05).In patients at 50～70 years old，the yin-deficiency constitution accounted for the most，and in patients at 71～80 years old，the yang-deficiency constitution the most.There was significant difference in the comparison of Chinese medicine constitution type between different disease courses(P＜0.05).Patients whose disease course less than five years accounted for more in the yin-deficiency constitution than the other two disease-course groups；patients whose disease course over eight years accounted for more than the other two disease-course groups.In terms of syndrome differentiation，the syndrome of qi and blood deficiency accounted for the most， including 199 cases(36.2%)，followed by the syndrome of yin deficiency of liver and kidney including 141 cases(25.6%)， the syndrome of yang deficiency of kidney including 124 cases(22.5%)， the syndrome of qi stagnation and blood stasis including 74 cases(13.5%)，and the other syndromes including 12 cases(2.2%).The qi-deficiency constitution and the syndrome of qi and blood deficiency were positively correlated(P ＜ 0.05)；the yangdeficiency constitution and the syndrome of yang deficiency of kidney were positively correlated(P ＜ 0.05)；the blood-stasis constitution and the syndrome of qi stagnation and blood stasis were positively correlated(P ＜ 0.05)；the yin-deficiency constitution and the syndrome of yin deficiency of liver and kidney were positively correlated(P＜0.05).Conclusion：When at early stage，in senile patients with osteoporosis，the yin-deficiency constitution accounts for the most，and the bloodstasis constitution and the yang-deficiency constitution the most when at late stage.According this rule，in preventing and treating osteoporosis，it is advised to adopt treatment chosen according to the variability of an individual.Specifically，based on the theories of"preventive treatment of disease"and"treating deficiency syndrome with tonifying method"，patients should be differentiated on their constitution and Chinese medicine syndrome，and given daily dietary suggestions and treatments to nourish yin and tonify kidney，warm yang and activate blood circulation，and supplement essence and boost marrow.In this way，the incidence of osteoporosis could be reduced and the quality of life of patients improved.