Objective：To observe the clinical effect of sonophoresis of Chinese herbal medicine based on massage and nursing for scapulohumeral periarthritis.Methods：A total of 90 cases of patients with scapulohumeral periarthritis of colddampness stasis obstruction type were randomly divided into the control group and the observation group，45 cases in each group.Both groups were given massage and nursing measures such as health propaganda and education as well as psychological nursing.The observation group was additionally treated with sonophoresis of Chinese herbal medicine.Both groups were treated for five days a week for four weeks.Before and after treatment，the pain of shoulder joint was evaluated by Visual Analogue Scale(VAS)，the function of shoulder joint by Constant-Murley Shoulder Joint Function Assessment Scale，and the daily activity by the American Shoulder and Elbow Surgeons(ASES).The clinical effect in the two groups was compared.Results：After treatment，the clinical effect in the observation group was superior to that in the control group(P ＜0.05).The scores of VAS and ASES in the two groups were decreased when compared with those before treatment(P＜0.01)，and the scores in the observation group were lower than those in the control group(P ＜ 0.01).The scores of pain，activities of daily living and range of motion of shoulder joint in Constant-Murley Score and their total scores in the two groups were increased when compared with those before treatment(P＜ 0.01)；there was no significant difference being found in the comparison of the scores of muscle strength before and after treatment in the two groups(P＞ 0.05).The scores of pain，activities of daily living and range of motion of shoulder joint as well as their total scores in the observation group were all higher than those in the control group(P＜0.01).Conclusion：The therapy of sonophoresis of Chinese herbal medicine based on massage and nursing in treating scapulohumeral periarthritis can effectively relieve the pain and improve the joint function and activities of daily living of patients，with significant clinical effect.