Objective： To observe the clinical effect of Chinese herbal fumigation combined with hemoperfusion for uremic intractable pruritus.Methods：A total of 40 cases of patients with uremic intractable pruritus were selected as the study subjects，and were randomly divided into the control group and the treatment group，20 cases in each group.The control group was given routine hemodialysis combined with hemoperfusion，and the treatment group was additionally treated with Chinese herbal fumigation based on the treatment of the control group.After treatment，the clinical effect and related indexes in the two groups were compared and analyzed.Results：The total effective rate was 55.00% in the control group and 95.00% in the treatment group，the difference being significant(P ＜ 0.05).After treatment，the related indexes in the two groups were decreased after treatment，the difference being significant(P ＜ 0.05).After treatment，the comparison of the related indexes in the two groups showed significance in the difference(P＜0.05).The score of pruritus in the treatment group was lower than that in the control group，the difference being significant(P ＜ 0.05).Conclusion：The therapy of Chinese herbal fumigation combined with hemoperfusion has definite clinical effect in treating uremic intractable pruritus，which can relieve the clinical symptoms and improve quality of life.