Objective：To observe the clinical effect of yang-warming and qi-benefiting and detoxificating prescription for ulcerative colitis(UC)and discuss the possible mechanism of repairing the intestinal mucosa.Methods：Selected 120 cases of patients with UC and divided them into the observation group and the control group according to the random number table，with 60 cases in each group.Both groups were treated with bifidobacterium triple viable capsules，glutamine enteric-coated capsules and mesalazine enteric-coated tablets，while the observation group was additionally given the oral administration of yang-warming and qi-benefiting and detoxificating prescription.After treatment，compared the Chinese medicine syndrome scores，clinical effect，interleukin-1(IL-1β)，tumor necrosis factor- α(TNF- α)，trefoil factor 3(TFF3)，mucin 2(MUC2)and intestinal mucosa scores in the two groups.Results：The total effective rate in the observation group was 90.0%，being evidently higher than that of 76.7% in the control group(P＜0.05).Before treatment，there was no significant difference being found in the comparison of the single Chinese medicine syndrome scores in the two groups(P ＞ 0.05).After treatment，the symptom scores of abdominal pain，diarrhea，mucopurulent stool and tenesmus in the two groups were lower than those before treatment and the scores of each symptom in the observation group were lower than those in the control group，differences being significant(P＜0.05).Before treatment，there was no significant difference being found in the comparison of the levels of IL-1β，TNF-α，TFF3，MUC2 in the two groups(P ＞ 0.05).After treatment，the levels of IL-1β and TNF-α in the two groups were decreased when compared with those before treatment，while the levels of TFF3 and MUC2 were increased when compared with those before treatment；the levels of IL-1β and TNF-α in the observation group were lower than those in the control group and the levels of TFF3 and MUC2 were higher than those in the control group；the differences were significant(P ＜ 0.05).Before treatment，there was no significant difference being found in the comparison of the intestinal mucosa scores in the two groups(P＞ 0.05).After treatment，the intestinal mucosa scores in the two groups ware decreased when compared with those before treatment and the intestinal mucosa scores in the observation group were lower than those in the control group，differences being significant(P＜0.05).Conclusion：The application of yang-warming and qibenefiting and detoxificating prescription can improve the curative effect of UC，reduce the expressions of IL-1β and TNF-α，relieve the inflammatory reactions，enhance the expressions of TFF3 and MUC2，protect the intestinal mucosa.