Abstract： Objective： To observe the curative effect of enema with Dachengqi tang combined with comprehensive nursing measures for sepsis based on the routine treatment and nursing. Methods：A total of 85 cases of sepsis patients with syndrome of internal exuberance of toxic heat were selected as the research objects. According to the random number table method，they were divided into the observation group and the control group，45 and 40 cases in each group respectively. Both groups were given routine symptomatic treatment and nursing intervention，and the observation group was additionally intervened with enema with Dachengqi tang as well as comprehensive nursing measures. Both groups were treated for a week. Before and after treatment，the scores of Acute Physiology and Chronic Health Evaluation Scoring System(APACHE Ⅱ)， gastrointestinal dysfunction， General Comfort Questionnaire(GCQ) and sleep quality were assessed； the levels of plasma D-lactate were detected. After one week of treatment，the clinical effect in the two groups was evaluated. Results：After treatment， the total clinical effective rate was 86.67% in the observation group and 57.50% in the control group， the difference being significant(P＜0.05). The scores of APACHE Ⅱ and gastrointestinal dysfunction in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above two scores in the observation group were lower than those in the control group(P＜0.05). On the 3rd and 7th day after treatment respectively， the levels of plasma D- lactate in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels in the observation group were lower than those in the control group(P＜0.05). The scores of sleep quality in the two groups were decreased when compared with those before treatment(P＜0.05)；the scores of GCQ were increased when compared with those before treatment(P＜0.05)；the scores of sleep quality in the observation group was lower than that in the control group (P＜0.05)， and the score of GCQ was higher(P＜0.05). Conclusion： Based on the routine treatment and nursing， the additional treatment of enema with Dachengqi tang combined with comprehensive nursing measures for patients with sepsis can enhance the clinical effect， sleep quality and comfort degree， improve the disease and restore the gastrointestinal function.