Abstract：Objective：To observe the clinical effect of catgut embedment in point combined with wheat-grain size cone moxibustion for female chloasma. Methods：A total of 60 cases of female patients with chloasma were randomly divided into two groups， 30 cases in each group. The observation group was treated with catgut embedment in point combined with wheat- grain size cone moxibustion，and the control group was given oral administration of vitamin C tablets and vitamin E soft capsules combined with hydroquinone cream. Both groups were treated for eight weeks. The clinical effect of female patients with chloasma in the two groups was recorded. Results： The total effective rate was 90.00% in the observation group， higher than that of 83.33% in the control group， the difference being significant(P＜0.05). After treatment， the scores of MASI，SDS and DLQI in the observation group were improved，differences being significant(P＜0.05)；the scores of MASI and DLQI in the control group were improved，differences being significant(P＜0.05)，and there was no significant difference being found in the comparison of the SDS scores before and after treatment in the control group(P＞0.05). The improvement of scores of MASI， SDS and DLQI in the observation group was better than that in the control group， differences being significant(P＜0.05). There was no severe adverse reaction in the two groups. Conclusion： Catgut embedment in point combined with wheat-grain size cone moxibustion for female chloasma can improve clinical effect.