Abstract：Objective：To observe and analyze the effect and safety of Baofukang suppository for vaginitis. Methods：A total of 92 enrolled cases with vaginitis were randomly divided into the observation group and the control group，46 cases in each group. The observation group was given Baofukang suppository， and the control group was given clotrimazole suppository. Both groups were continuously treated with medicine for eight days. The scores of Nugent，intravaginal pH value and quality of life before and after treatment in the two groups were evaluated. The clinical effect，the incidence of adverse reactions，and the recurrence rate in the 1st month after treatment were compared between the two groups. Results：After treatment， the clinical total effective rate was 95.65% in the observation group and 71.74% in the control group， the difference being significant(P＜0.01). The scores of Nugent and intravaginal pH value in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05)；the two scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). In the two groups， the scores of physical health，psychological state，independent ability，spiritual support，social relation and surrounding environment as well as the total score in the World Health Organization Quality of Life- 100(WHOQOL- 100) Scale were increased when compared with those before treatment(P＜0.05)；each score as well as the total score in the observation group was higher than that in the control group(P＜0.05). During treatment，no adverse reactions occurred in the two groups. After one- month medicine withdrawal，the recurrence rate was 2.27% in the observation group and 24.24% in the control group，the difference being significant(P＜0.05). Conclusion：Baofukang suppository has good curative effect on various vaginitis，which can effectively relieve symptoms of vaginitis and reduce recurrence， as well as significantly improve the quality of life without adverse reactions.