Abstract：Objective：To observe the clinical effect of Qiju Dihuang pills combined with sodium hyaluronate eye drops for dry eyes. Methods：A total of 180 cases of patients with dry eyes of qi-yin deficiency type were divided into the control group and the observation group according to the random number table method，90 cases in each group. Both groups were given routine treatments such as anti- inflammation， artificial tears and repair of corneal wound. The control group was given sodium hyaluronate eye drops，and the observation group was given Qiju Dihuang pills combined with sodium hyaluronate eye drops. The clinical effect， and the changes in the tear break- up time(BUT)， the Schirmer's Test(SIT)， the symptom scores of dry eyes，and the scores of fluorescein staining of a single eye cornea were compared between the two groups. Results：The total effective rate was 95.56% in the observation group，higher than that of 86.67% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of BUT and SIT between the two groups(P＞0.05). After two-week and four-week treatment，the levels of BUT and SIT in the two groups were gradually increased，and the two levels in the observation group were higher than those in the control group at the same time point， differences being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the symptom scores of dry eyes and the scores of fluorescein staining of a single eye cornea between the two groups(P＞0.05). After two-week and four-week treatment，the symptom scores of dry eyes and the scores of fluorescein staining of a single eye cornea in the two groups were gradually decreased，and the two scores in the observation group were lower than those in the control group at the same time point，differences being significant (P＜0.05). Conclusion：The therapy of Qiju Dihuang pills combined with sodium hyaluronate eye drops in treating dry eyes， can significantly improve the eye symptoms，and increase stability of tear film with better clinical effect.