Abstract：Objective：To observe the clinical effect of Duhuo Jisheng tang combined with specific electromagnetic wave spectrum(TDP) and warming-needle moxibustion for knee osteoarthritis. Methods：A total of 86 cases of patients with knee osteoarthritis were selected as research objects and randomly divided into the observation group and the control group ， 43 cases in each group. The observation group was treated with Duhuo Jisheng tang combined with TDP and warmingneedle moxibustion，and the control group was given celecoxib capsules treatment. Both groups were treated for 30 days. The scores of Visual Analogue Scale(VAS)，Lysholm Knee Function Scale and grading and quantification of Chinese medicine symptoms and signs before and after treatment， as well as the clinical effect and incidence of adverse reactions after treatment in the two groups were compared. Results：After treatment for 10 days，the total effective rate was 88.37% in the observation group and 69.77% in the control group， the difference being significant(P＜0.05)； the scores of grading and quantification of Chinese medicine symptoms and signs in the two groups were decreased when compared with those before treatment，and the score in the observation group was lower than that in the control group，differences being significant(P＜ 0.05). After treatment for 30 days，the total effective rate was 95.35% in the observation group and 81.40% in the control group，the difference being significant(P＜0.05)；the scores of grading and quantification of Chinese medicine symptoms and signs in the two groups were decreased when compared with those before treatment and after 10 days of treatment respectively(P＜0.05)，and the scores in the observation group were lower than those in the control group(P＜0.05). The VAS scores in the two groups were decreased when compared with those before treatment and Lysholm scores were increased， differences being significant(P＜0.05). The VAS score in the observation group was lower than that in the control group and Lysholm score was higher， differences being significant(P＜0.05). The incidence of adverse reactions was 13.95% in the control group and 0 in the observation group， the difference being significant(P＜0.05). The examination results of blood routine，urine routine liver function and kidney function in the two groups were normal. Conclusion：The therapy of Duhuo Jisheng tang combined with TDP and warming- needle moxibustion for knee osteoarthritis can effectively relieve local pain， and improve the activity function of knee joint，which is safe and effective.