Abstract： Objective： To discuss the correlation between pathological stage of the liver fibrosis， Chinese medicine constitution and FibroScan in patients with chronic hepatitis B. Methods：A total of 341 cases of patients with chronic hepatitis B undergoing the liver biopsy in our hospital were retrospectively studied and analyzed. All the patients were assigned to different stages based on The Guideline of Prevention and Treatment for Chronic Hepatitis B(2015 Version). All the patients were divided into different groups according to the degree of the liver fibrosis；the constitution analysis was conducted based on nine constitution types in Chinese medicine. The values of instantaneous elasticity，namely，liver stiffness measurement (LSM) and controlled attenuation parameter(CAP) were tested through FibroScan；the examination of the liver function was conducted；the relationship between the above indexes and the fibrosis degree was discussed. Results：Among a total of 341 cases of patients undergoing the liver biopsy， the balanced constitution accounted for 3.81% ， the qi- deficiency constitution 18.77%，the qi- depression constitution 27.27%，the dampness- heat constitution 13.78%，the dampness- phlegm constitution 34.31% ， the yang- deficiency constitution 0.59% ， the static blood constitution 1.17% ， the special intrinsic constitution for zero and the yin-deficiency constitution accounting for 0.29%；all the patients were divided into three groups according to the fibrosis degree；after statistical analysis，it was found that the proportion of the dampness-phlegm constitution was the highest in all the three groups；differences were significant(P＜0.05). There was correlation between the fibrosis degree and LSM，CAP as well as AST/ALT(Aspartate aminotransferase/Alanine aminotransferase)，differences being significant(P＜0.05). Based on the indexes of LSM， CAP and AST/ALT， the patients with obvious liver fibrosis or cirrhosis were selected and regrouped respectively； the ROC curve analysis was conducted. In terms of the diagnosis of obvious fibrosis of hepatitis B， the AUC of LSM， CAP and AST/ALT in ROC curve was 0.800， 0.371 and 0.628 respectively； the sensitivity of the above three indexes was 0.741，0.509 and 0.679 respectively；the specificity of the above three indexes was 0.788，0.491 and 0.520 respectively；the highest diagnostic efficiency was LSM，followed by AST/ALT and CAP，the difference being significant(P＜0.05). In terms of the diagnosis of cirrhosis in patients with hepatitis B，the AUC of LSM，CAP and AST/ALT in ROC curve was 0.911，0.477 and 0.627 respectively，and the P value of CAP in ROC curve was more than 0.05，there was no significance in the difference. The sensitivity of LSM and AST/ALT in diagnosis of the liver cirrhosis was 0.852 and 0.593 respectively； the specificity of the above two indexes was 0.855 and 0.618 respectively， the difference being significant(P＜0.05). Conclusion：The largest group in patients with the liver fibrosis at each stage was patients with the dampness-phlegm constitution. In each commonly-used diagnostic index，LSM，CAP and AST/ALT are more closely related to the degree of the liver fibrosis，and LSM has higher diagnostic value in patients with the liver cirrhosis.