Abstract：Objective：To observe the clinical value of Shenshuaining capsules combined with Chinese medicine nursing for chronic renal failure(CRF) in early and middle stage. Methods： A total of 102 cases of CRF patients in early and middle stage were randomly divided into the control group and the observation group，51 cases in each group. The control group was given routine treatment and nursing， and the observation group was additionally given Shenshuaining capsules combined with Chinese medicine nursing based on the treatment of the control group. Before and after treatment，the scores of clinical symptoms and the levels of hemoglobin(Hb)，albumin(Alb)，24- hour urine protein quantification(24 h UPQ)，uric acid(UA) serum creatinine(SCr)， blood urea nitrogen(BUN)， creatinine clearance rate(CCr) and serum cystatin C(Cys- C) in the two groups were compared. Results： Before treatment， there was no significant difference being found in the comparison of scores of clinical symptoms between the two groups(P＞0.05). After treatment，the scores of poor appetite，limb numbness and tastelessness and hydroadipsia in the two groups were decreased when compared with those before treatment，and the decrease in the observation group was more significant than that in the control group， and the improvement in the observation group was better， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the contents of Hb，Alb，24 h UPQ and UA between the two groups(P＞0.05). After treatment， the contents of Hb， Alb and 24h UPQ in the control group were significantly decreased when compared with those before treatment，and the 24 h UPQ content in the observation group was decreased，and the decrease in the observation group was larger than that in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of SCr，BUN，CCr and Cys-C between the two groups(P＞0.05). After treatment， the Cys- C level in the control group was decreased when compared with that before treatment，and the levels of SCr，BUN and Cys-C in the observation group were significantly decreased，and the CCr level was increased； the improvement in the observation group was better than that in the control group， the difference being significant(P＜0.05). Conclusion：The application of Shenshuaining capsules combined with Chinese medicine nursing for CRF patients in early and middle stage can significantly relieve clinical symptoms and improve kidney function.