Abstract： Objective： To observe the clinical effect of pricking and blood letting combined with qianzheng powder for peripheral facial paralysis. Methods：A total of 128 cases of patients with peripheral facial paralysis were randomly divided into the control group and the observation group， 64 cases in each group. The control group was treated with mouse nerve growth factor for injection and cattle encephalon glycoside and ignotin injection，and the observation group was additionally treated with pricking and bloodletting combined with oral administration of qianzheng powder based on the treatment of the control group. Before and after treatment，the changes in syndrome scores of mouth-eye deviation，droopy eyelids and food stagnation in the two groups were observed and compared. The scores of House Brackmann for facial nerve grading and Facial Dysfunction Index(FDI) were compared between the two groups before and after treatment. The time for healing and total clinical effect were compared between the two groups. Results：The total effective rate was 92.19% in the observation group and 79.69% in the control group，the difference being significant(P＜0.05). After treatment，the syndrome scores of moutheye deviation， droopy eyelids and food stagnation in the two groups were decreased when compared with those before treatment(P＜0.05)， and each score in the observation group was lower than that in the control group(P＜0.05). After treatment，the scores of House- Brackmann and FDI in the two groups were increased when compared with those before treatment(P＜0.05)，and the two indexes in the observation group were both higher than those in the control group(P＜0.05). After treatment，the average healing time in the observation group was significantly shorter than that in the control group， the difference being significant(P＜0.05). Conclusion： Based on mouse nerve growth factor for injection and cattle encephalon glycoside and ignotin injection， the therapy of pricking and bloodletting combined with qianzheng powder for peripheral facial paralysis can significantly relieve clinical symptoms，promote the recovery of facial nerve function，whose curative effect is better than that of simple western medicine.