Abstract：Objective：To observe the clinical effect of acupuncture at three points along three yang meridians of the hand and cervical Jiaji point(Ex-B2) for cervical spondylotic radiculopathy(CSR). Methods：A total of 68 CSR patients were selected and divided into the study group and the control group according to the random number table method， 34 cases in each group. Four patients discontinued the study in the study group and five patients in the control group. The control group was given acupuncture at cervical Jiaji point(Ex-B2)， and the study group was additionally given acupuncture at three points along three yang meridians of the hand based on the treatment of the control group. Both groups were continuously treated for seven days. Before and after treatment， the scores of the Short- Form McGill Pain Questionnaire(SF- MPQ)， Short Form 36-Item Health Survey(SF-36) and Tanaka Yasuku Cervical Spondylosis Symptoms Scale with 20 points as well as the levels of tumor necrosis factor- α(TNF- α) and interleukin- 6(IL- 6) in serum were compared between the two groups. The clinical effect was compared between the two groups. Results：The total effective rate was 100% in the study group and 79.31% in the control group， the difference being significant(P＜0.05). After treatment， the scores of physical functioning(PF)， role physical(RP)， bodily pain(BP)， general health(GH)， vitality(VT)， social functioning(SF)， role emotional(RE) and metal health (MH) in the two groups were increased when compared with those before treatment；the increase of the above eight scores in the study group was more significant，differences were significant(P＜0.05). After treatment， the scores of Pain Rating Index(PRI)， Visual Analogue Scale(VAS) and Present Pain Intensity(PPI) as well as the total score in the two groups were decreased when compared with those before treatment；the decrease of the above three scores with detailed rules as well as the total score in the study group was more significant，differences were significant(P＜0.05). After treatment， the scores of symptoms and signs， activities of working and daily living， and the hand function as well as the total score were increased when compared with those before treatment，the increase of the above four scores with detailed rules as well as the total score in the study group was more significant，differences were significant(P＜0.05). After treatment， the levels of TNF-α and IL-6 in serum in the two groups were decreased when compared with those before treatment；the decrease of the two levels in the study group was more significant， differences were significant(P＜0.05). Conclusion： The therapy of acupuncture at three points along three yang meridians of the hand and cervical Jiaji point(Ex- B2) for CSR，can effectively improve symptoms and signs， promote the quality of life， and reduce the level of pro-inflammatory factors.