Abstract：Objective：To observe the curative effect of Xiao'er Chaigui Tuire granules combined with ribavirin aerosol for acute upper respiratory infection(AURI) in children and its effect on high-sensitivity C-reactive protein(hs-CRP) in serum and immune function. Methods： A total of 100 cases of AURI children were divided into the observation group and the control group according to the odd- even number grouping method， 50 cases in each group. Both groups were given routine symptomatic and supportive treatment after admission；the control group was given ribavirin aerosol；the observation group was additionally given Xiao'er Chaigui Tuire granules based on the treatment of the control group. After treatment，the clinical effect and the changes in hs-CRP in serum and immune function indexes were compared between the two groups. Results： The total clinical effective rate was 96.00% in the observation group and 72.00% in the control group，the difference being significant(P＜0.05). The disappearance time of cough and sore throat，nasal obstruction and discharge，as well as fever in the observation group was significantly earlier than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of hs-CRP level in serum between the two groups(P ＞ 0.05). After treatment，the hs-CRP levels in serum in the two groups were significantly decreased when compared with those before treatment， and the level in serum in the observation group was lower than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the values of CD4+，CD8+ and CD4+/CD8+ between the two groups(P＞0.05). After treatment， the values of CD4 + and CD4 +/CD8 + in the two groups were increased when compared with those before treatment， and the two values in the observation group were significantly higher than those in the control group(P＜0.05)；the CD8 + values in the two groups were significantly decreased when compared with those before treatment，and the value in the observation group was significantly lower than that in the control group(P＜0.05). During treatment，there was one cases of leukocyte decrease in the observation group and two cases in the control group， and no adverse reactions of other medicine occurred. After one- week drug withdrawal， leukocytes returned to normal. Conclusion： The therapy of Xiao'er Chaigui Tuire granules combined with ribavirin aerosol has defined curative effect in treating AURI in children， which can effectively relieve their clinical syndromes and signs， inhibit inflammatory response， and improve immunity with high medicine safety.