化斑丸联合阿司匹林肠溶片及阿托伐他汀钙片治疗颈动脉斑块临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R541.4

基金项目:

开封市科技发展计划项目(1703047)


Clinical Study on Huaban Pills Combined with Aspirin Enteric- Coated Tablets and Atorvastatin Calcium Tablets for Carotid Plaques
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察化斑丸联合阿司匹林肠溶片、阿托伐他汀钙片治疗颈动脉粥样硬化斑块的临床疗效。方法:将颈动脉粥样硬化斑块患者100 例随机分为治疗组和对照组,每组50 例。2 组患者均常规控制危险因素,对照组给予阿司匹林肠溶片、阿托伐他汀钙片治疗,治疗组在对照组的基础上加用化斑丸治疗,2 组疗程均为6 个月。观察比较2 组临床疗效、中医症状评分、斑块积分、脑血管事件及血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平变化。结果:总有效率治疗组为86.00%,对照组为44.00%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组患者头晕、腰膝酸软、耳鸣、头身困重、头刺痛等中医症状评分均较治疗前明显降低(P<0.05),且治疗组各项评分均明显低于对照组(P<0.05)。治疗后,2 组血清TC、TG、LDL-C 水平均较治疗前明显降低(P<0.05),HDL-C 水平略升高(P>0.05);2 组间上述各项指标比较,差异无统计学意义(P>0.05)。治疗后,2 组左右侧颈动脉粥样硬化斑块积分均较治疗前减小(P<0.05);且治疗组左右侧斑块积分均小于对照组(P<0.05)。随访6 个月,2 组患者均未发生脑血管事件。治疗期间2 组均未发生治疗相关不良反应。结论:化斑丸联合阿司匹林肠溶片、阿托伐他汀钙片治疗颈动脉粥样硬化斑块患者,能够显著改善其临床症状,减少斑块积分,降低血脂水平,有效预防脑血管事件。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Huaban pills combined with aspirin enteric- coated tablets and atorvastatin calcium tablets for carotid atherosclerotic plaques. Methods: A total of 100 cases of patients with carotid atherosclerotic plaques were randomly divided into the treatment group and the control group, 50 cases in each group. In both groups, risk factors were routinely controlled. The control group was treated with aspirin enteric- coated tablets and atorvastatin calcium tablets,and the treatment group was additionally treated with Huaban pills based on the treatment of the control group. Both groups were treated for six months. The clinical effect,and the changes in Chinese medicine symptom scores, plaque scores, cerebrovascular events as well as the levels of the total cholesterol(TC), triglyceride(TG), highdensity lipoprotein cholesterol(HDL- C) and low- density lipoprotein cholesterol(LDL- C) in serum in the two groups were observed and compared. Results: The total effective rate was 86.00% in the treatment group and 44.00% in the control group, the difference being significant(P<0.05). After treatment, the scores of Chinese medicine symptoms such as dizziness, lassitude in loin and knee, tinnitus, heaviness in head and body and twinge in head in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above scores in the treatment group were significantly lower than those in the control group(P<0.05). After treatment,the levels of TC,TG and LDL-C in serum in the two groups were significantly decreased when compared with those before treatment(P<0.05), and the levels of HDL- C were increased slightly(P>0.05); there was no significant difference being found in the comparisons of the above indexes between the two groups(P>0.05). After treatment,the scores of carotid atherosclerotic plaques in both left and right sides in the two groups were decreased when compared with those before treatment(P<0.05), and the scores in the treatment group were lower than those in the control group(P<0.05). After follow- up for six months, no cerebrovascular events occurred in the two groups. During the treatment,no treatment-related adverse reactions occurred in the two groups. Conclusion: The therapy of Huaban pills combined with aspirin enteric- coated tablets and atorvastatin calcium tablets for patients with carotid atherosclerotic plaques can significantly improve their clinical symptoms, reduce plaque scores and levels of blood lipid,and effectively prevent cerebrovascular events.

    参考文献
    相似文献
    引证文献
引用本文

张玲,孙会秀,李柱,李新民,刘政伟,卢要强,李义松,刘作印.化斑丸联合阿司匹林肠溶片及阿托伐他汀钙片治疗颈动脉斑块临床研究[J].新中医,2020,52(17):95-99

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2020-09-06
  • 出版日期: