Abstract： Objective： To observe the clinical effect of oral administration of Chinese medicine combined with point injection of radix astragali injection for gastroesophageal reflux disease(GERD). Methods： A total of 124 cases of GERD patients were divided into the study group and the control group according to the random number table method，62 cases in each group. The control group was given omeprazole enteric capsules combined with mosapride citrate tablets，and the study group was additionally treated with oral administration of Chinese medicine and point injection of radix astragali injection based on the treatment of the control group. Both groups were continuously treated for eight weeks. Chinese medicine syndrome scores and the times and duration of gastroesophageal reflux before and after treatment，as well as the clinical effect were compared between the two groups. The incidence of adverse reactions was observed. After two- month medicine withdrawal，the recurrence rate was counted. Results：The total effective rate was 96.77% in the study group，better than that of 85.48% in the control group， the difference being significant(P＜0.05). After treatment， the scores of acid regurgitation， heartburn， substernal burning sensation， fullness in the chest and hypochondrium as well as vexation and irascibility in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above five scores in the study group were lower than those in the control group(P＜0.05). After treatment，the total times of reflux in 24 hours and the times of the duration equal or longer than 5 minutes in the two groups were reduced when compared with those before treatment(P＜0.05)，and the longest duration of reflux was shorter(P＜0.05). The total times of reflux in 24 hours and the times of the duration equal or longer than 5 minutes in the study group were less than those in the control group(P＜ 0.05)，and the longest duration of reflux was shorter(P＜0.05). During treatment，there was no significant adverse reaction or complication in the two groups. The recurrence rate was 11.67% in the study group and 28.30% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of oral administration of Chinese medicine combined with point injection of radix astragali injection in treating GERD can effectively improve clinical symptoms and reduce recurrence rate， without significant adverse reaction.