Objective：To observe the clinical effect of modified Guixian tang combined with femonston for premature ovarian failure(POF)of kidney deficiency and liver depression type.Methods：A total of 81 cases of patients with POF of kidney deficiency and liver depression type were selected as study subjects and divided into the Chinese medicine group，the western medicine group and the Chinese and western medicine group(the combination group)according to the random number table method，28，26 and 27 cases in each group respectively.The Chinese medicine group was treated with modified Guixian tang；the western medicine group was treated with femonston；the combination group was treated with modified Guixian tang and femonston.All groups were treated for three months.The clinical effect in the three groups was compared；the changes in the Chinese medicine symptom scores and the levels of follicle-stimulating hormone(FSH)，estradiol(E2)and luteinizing hormone(LH)in serum before and after treatment were observed；the incidence of adverse reactions was recorded.Results：The total effective rate was 96.3% in the combination group，higher than that of 73.1% in the western medicine group respectively，difference being significant(P ＜ 0.05).After treatment，the Chinese medicine symptom scores in the three groups were decreased when compared with those before treatment，differences being significant(P ＜ 0.05)；the score in the combination group was lower than that in the Chinese medicine group and that in the western medicine group respectively(P＜ 0.05)；the score in the Chinese medicine group was lower than that in the western medicine group(P＜ 0.05).After treatment，the levels of FSH，LH and E2in the three groups were improved when compared with those before treatment，differences being significant(P ＜ 0.05)；the improvement of levels of the above three sex hormones in the combination group was superior to that in the western medicine group and that in the Chinese medicine group(P ＜ 0.05)；the improvement of level of E2in the western medicine group was better than that in the Chinese medicine group(P＜0.05).There was no obvious adverse reaction during the treatment in the three groups.Conclusion：The therapy of modified Guixian tang combined with femonston in treating POF of kidney deficiency and liver depression type can effectively improve clinical symptoms and levels of sex hormones of patients，whose curative effect is superior to that of the simple use of one of them.