Objective： To observe the protective effect of Danshen Chuanxiongqin injection combined with western medicine on brain tissue in patients with acute ischemic stroke and its effect on prognosis.Methods：A total of 268 cases of patients with acute ischemic stroke were selected as the study subjects，and were divided into the study group and the control group according to the random number table method，134 cases in each group.Both groups were treated with western medicine，and the study group was additionally treated with Danshen Chuanxiongqin injection.Both groups were followed up for 12 weeks.Before and after treatment，the levels of the inflammatory factors in serum including highsensitivity C-reactive protein(hs-CRP)，tumor necrosis factor- α(TNF- α)，interleukin-6(IL-6)and interleukin-8(IL-8)，the vascular endothelial growth factor(VEGF)， the neuron-specific enolase(NSE)and the S-100β in the two groups were detected.The scores of National Institutes of Health Stroke Scale(NIHSS)and Barthel Index(BI)of patients within 12 weeks of treatment were evaluated during follow-up.Results：After treatment for three weeks，the levels of hs-CRP，TNF-α，IL-6 and IL-8 in the two groups were lower than those before admission(P ＜ 0.01)；and the levels in the study group were lower than those in the control group(P＜0.01).The levels of NSE and S-100β in serum in the two groups were decreased when compared with those before admission(P＜ 0.01)，and the levels of VEGF were increased when compared with those before admission(P ＜ 0.01).The levels of NSE and S-100β in serum in the study group were lower than those in the control group，and the level of VEGF was higher than that in the control group，differences being significant(P＜0.01).The NIHSS scores at a time point after treatment in both groups were lower than those before treatment in the same group respectively(P＜0.01)，while the BI scores at a time point after treatment in both groups were higher than those before treatment in the same group respectively(P＜ 0.01).At the 6thand 12thweeks of treatment，NIHSS score in the study group was lower than that in the control group(P＜0.01)，while BI score was higher(P＜0.01).Conclusion：The therapy of Danshen Chuanxiongqin injection combined with western medicine in treating patients with acute ischemic stroke can effectively reduce the degree of vascular inflammatory responses and the damage degree of vascular endothelial cells and brain tissue，promote the recovery of neurons in the cerebrum，improve living ability after stroke，prevent limb dysfunction after stroke and improve the prognosis of patients.