Objective： To observe the clinical effect of Shensong Yangxin capsules combined with bisoprolol for arrhythmia complicated with brain-heart syndrome.Methods：A total of 66 patients with arrhythmia complicated with brain-heart syndrome were selected and divided into two groups according to the random number table.The 33 patients in the control group were treated with bisoprolol，and the other 33 patients in the observation group were treated with Shensong Yangxin capsules combined with bisoprolol.The changes of the levels of catecholamine，heart rate variability，malondialdehyde(MDA)， superoxide dismutase in serum(SOD)， endothelin-1(ET-1)and nitric oxide(NO)before and after treatment in the two groups were compared.Results：The levels of catecholamine epinephrine(E)，norepinephrine(NE)and dopamine(DA)in the observation group were decreased when compared with those in the control group，differences being significant(P＜ 0.05).The standard deviation of normal to normal of sinus R-R interval(SDNN)，the standard deviation of sequential five-minute of sinus R-R interval means(SDANN)，the root mean square of the successive differences of R-R interval(rMSSD)，and the proportion of the difference of heartbeat between two adjacent R-R intervals more than 50ms during the analysis over the number of heartbeat(PNN50%)in the observation group were all increased when compared with those in the control group，differences being significant(P＜0.05).The levels of MDA，ET-1 and NO in the observation group were decreased when compared with those in the control group，and levels of SOD were increased，the difference being significant(P＜0.05).Conclusion：The therapy of Shensong Yangxin capsules combined with bisoprolol has significant effect in treating patients with arrhythmia complicated with brain-heart syndrome，which can effectively reduce the level of catecholamine and improve the heart rate variability.