Insect medicine belongs to animal Chinese medicine，which refers to a part of the animals whose whole or part of the body or products can be used as medicine.It is a product of“flesh and blood”and“insects”，with unique biological activity and effect in treating difficult and complicated diseases.Although YE Tianshi was good at using light and flexible Chinese medicine，he often used insect medicine to reach the root of the diseases directly as well.In clinical practice，he chose insect medicine flexibly，and valued its effect of dispelling wind and detoxifying，breaking blood and expelling stasis，moving qi and activating blood，tonifying and replenishing to consolidate the foundation，eliminating hardness and dissipate binds，dispersing abscesses and swelling，extinguishing wind and settling fright，diffusing and upraising qing-yang as well as diffusing wind and discharging heat.The methods of administration mainly included decoction，pill preparation，powder preparation， paste preparation， liniment and Pharmaceuticals for Twisting Yarns.Better curative effect can be obtained through the study and summary of YE Tianshi's experience of applying insect medicine，and the flexible application based on accurate syndrome differentiation.