To investigate the effect of written expression combined with emotional support of family members on the improvement of perceived stress，depression and sleep quality in patients with advanced colon cancer.Methods：A total of 86 cases of patients with advanced colon cancer were selected and divided into the experiment group and the control group according to random number table method，43 cases in each group.The control group adopted routine health education and psychological care，and the experiment group was additionally intervened with written expression combined with emotional support of family members based on the treatment of the control group.Before and after the intervention，Chinese Perceived Stress Scale(CPSS)，Center for Epidemiological Survey(CES-D)and Pittsburgh sleep quality index(PSQI)were used to evaluate the effect of the intervention.Results：Before intervention，there was no statistically significant difference in the comparison of scores of CPSS，CES-D and PSQI between the two groups(P＞ 0.05).After intervention，the scores of CPSS，CES-D and PSQI in the experiment group were significantly lower than those before intervention and those in the control group，differences being significant(P ＜ 0.05).Conclusion：The therapy of written expression combined with emotional support from family members can reduce the perceived stress，relieve depression and improve sleep quality in patients with advanced colon cancer，which has significant clinical value.