To observe the effect of Shenqi Fuzheng injection on cancer-related fatigue and metabolic status in postoperative patients with gastric cancer.Methods：Selected 66 cases of postoperative patients with gastric cancer as study subjects，and divided them into the control group and the observation group randomly，33 cases in each group.The control group received routine postoperative treatment for gastric cancer，while the observation group additionally received Shenqi Fuzheng injection.Compared the scores of cancer-related fatigue and indexes of lipid metabolism and protein metabolism in both groups before and after treatment.Results：Before treatment，comparing the scores of cancer-related fatigue in both groups，there were no significant differences being found(P ＞ 0.05).After treatment，the scores of body，cognition，emotion and comprehensive fatigue in the observation group were significantly lower than those before treatment，being lower than those in the control group in the same period，differences being significant(P ＜ 0.05)；after treatment for two weeks，the scores of bodily fatigue in the control group were lower than those before treatment(P ＜ 0.05).Before treatment，comparing the indexes of lipid metabolism in both groups，there were no significant differences being found(P ＞ 0.05).After treatment，the indexes of lipid metabolism in both groups were improved continuously，and the evaluation and detection results in the observation group were significantly better than those in the control group，differences being significant(P＜0.05).Before treatment，comparing the indexes of protein metabolism in both groups，there were no significant differences being found(P ＞ 0.05).After treatment，the indexes of protein metabolism in both groups were improved continuously，and the evaluation and detection results in the observation group were significantly better than those in the control group，differences being significant(P＜0.05).Conclusion：Shenqi Fuzheng injection helps release cancer-related fatigue in postoperative patients with gastric cancer and assists in regulating the bodily metabolic status，which is well worthy of clinical application.