To observe the effect of aerosol inhalation of recombinant human interferon α-2b combined with Shegan Mahuang tang on the expression levels of serum interleukin-13(IL-13)，eosinophil cationic protein(ECP)and T lymphocyte subsets in the peripheral blood of children with bronchiolitis.Methods：Divided 220 cases of children with bronchiolitis and wind-cold invading lung syndrome into two groups randomly，110 cases in each group.The control group received aerosol inhalation of recombinant human interferon α-2b，while the observation group additionally received the oral administration of Shegan Mahuang tang.Observed the clinical effect，adverse reactions and the levels of serum IL-13，IL-4，ECP，interferon-γ(IFN-γ)and T lymphocyte subsets in both group.Results：The total effective rate was 98.18%in the observation group and 81.82%in the control group，difference being significant(P ＜ 0.05).After treatment，the recovery time of heart rate，the time of hospitalization，the remission time of short breath and the disappearance time of coughing，moist rales and wheezing rales in the observation group were all shorter than those in the control group(P ＜ 0.05).After treatment，the contents of serum CD3+，CD4+and the level of CD4+/CD8+in both groups were high than those before treatment(P＜0.05)，and the content of serum CD8+was lower than that before treatment(P ＜ 0.05)；each index above in the observation group was improved better than that in the control group(P ＜ 0.05).After treatment，the contents of serum IL-13，IL-4 and ECP in both groups were lower than those before treatment(P ＜ 0.05)，and the content of IFN-γ was high than that in the control group(P ＜ 0.05)；each index above in the observation group was improved better than that in the control group(P＜0.05).During treatment， no significant adverse reactions occurred in both groups.Conclusion： Shegan Mahuang tang combined with aerosol inhalation of recombinant human interferon α-2b for bronchiolitis in children with wind-cold invading lung syndrome can effectively relieve the clinical symptoms of patients，maintain the balance of Th1/Th2 and improve their bodily immune function.It has better therapeutic effect than simple western medicine.