To observe the effect of Yiqi Bushen Zhichuan tang combined with routine western medicine for asthma in children，and its effect on the lung function and the indexes of airway reactivity in children.Methods：A total of 86 cases of children with asthma of spleen-kidney qi deficiency type were selected as the study subjects，and randomly divided into the observation group and the control group，43 cases in each group.Both groups were treated with routine western medicine，and the observation group was additionally treated with Yiqi Bushen Zhichuan tang.The improvement time of clinical symptoms and the levels of inflammatory indexes including C-reactive protein(CRP)， tumor necrosis factor-α(TNF-α)，white blood cell count(WBC)and neutrophil(NEUT)count，the lung function indexes including forced vital capacity(FVC)， maximal voluntary ventilation(MVV)， forced expiratory volume in one second(FEV1)， the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)and maximal midexpiratory flow(MMF)，as well as the indexes of airway reactivity including the provocation dose(PD35)and the minimum dose(Dmin)of acetylcholine causing a 35%decrease in total respiratory air conduction and specific respiratory system conductance(SGrs)before and after treatment in the two groups were compared.Results： After treatment， the fever subsidence time， the disappearance time of wheezes and wheezing sound and the remission time of dyspnea in the observation group were shorter than those in the control group，differences being significant(P＜0.01).After treatment，the levels of CRP，TNF-α，WBC and NEUT in the two groups were decreased when compared with those before treatment(P ＜ 0.05)，and the above four indexes in the observation group were lower than those in the control group(P ＜ 0.05).After treatment for one month and three months，the levels of FVC，FEV1，FEV1/FVC，MVV and MMF in the two groups were increased when compared with those before treatment respectively(P＜0.05)，the above five indexes in the observation group were higher than those in the control group(P ＜ 0.05).The levels of PD35，Dmin and SGrs in the two groups were increased when compared with those before treatment(P ＜ 0.05)，and the above three indexes in the observation group were higher than those in the control group(P＜0.05).Conclusion：The therapy of Yiqi Bushen Zhichuan tang combined with routine western medicine in treating children with asthma of spleen-kidney qi deficiency type can improve the clinical symptoms more rapidly，effectively reduce the injury of airway，improve the lung function，and further improve the curative effect.