益气补肾止喘汤联合常规西药治疗小儿哮喘临床研究
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R725.6

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Clinical Study on Yiqi Bushen Zhichuan Tang Combined with Routine Western Medicine for Asthma in Children
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    摘要:

    目的:观察益气补肾止喘汤联合常规西药治疗小儿哮喘的效果,与对患儿肺功能及气道反应指标的影响。方法:选择86例脾肾气虚型哮喘患儿作为研究对象,随机分为观察组和对照组各43例,2组患儿均给予常规西药治疗,观察组加予益气补肾止喘汤治疗。比较2组患儿的临床症状改善时间,治疗前后的炎症指标 [C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞计数 (WBC) 及中性粒细胞计数(NEUT)]、肺功能指标 [用力肺活量(FVC)、最大通气量(MVV)、第1秒用力呼气容积(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)及中间呼气流量(MMF)]及气道反应指标[总呼吸气导下降35%所需的乙酰胆碱累积量(PD35)、反应阈值(Dmin)及传导率下降斜率(SGrs)]水平。结果:治疗后,观察组退热时间、喘憋消失时间、哮鸣音消失时间及气促缓解时间均较对照组缩短,差异均有统计学意义(P<0.01)。2组CRP、TNF-α、WBC及NEUT均较治疗前降低(P<0.05),观察组4项指标值均低于对照组(P<0.05)。治疗1个月、3个月时,2组FVC、FEV1、FEV1/FVC、MVV及MMF均较治疗前升高(P<0.05),观察组5项指标值均高于对照组(P<0.05)。2组PD35、Dmin及SGrs均较治疗前升高(P<0.05),观察组3项指标值均高于对照组(P<0.05)。结论:益气补肾止喘汤联合常规西药治疗脾肾气虚型哮喘患儿,可更为快速地改善哮喘患儿的临床症状,有效减轻气道损伤,提高肺功能,进一步提高疗效。

    Abstract:

    To observe the effect of Yiqi Bushen Zhichuan tang combined with routine western medicine for asthma in children,and its effect on the lung function and the indexes of airway reactivity in children.Methods:A total of 86 cases of children with asthma of spleen-kidney qi deficiency type were selected as the study subjects,and randomly divided into the observation group and the control group,43 cases in each group.Both groups were treated with routine western medicine,and the observation group was additionally treated with Yiqi Bushen Zhichuan tang.The improvement time of clinical symptoms and the levels of inflammatory indexes including C-reactive protein(CRP), tumor necrosis factor-α(TNF-α),white blood cell count(WBC)and neutrophil(NEUT)count,the lung function indexes including forced vital capacity(FVC), maximal voluntary ventilation(MVV), forced expiratory volume in one second(FEV1), the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)and maximal midexpiratory flow(MMF),as well as the indexes of airway reactivity including the provocation dose(PD35)and the minimum dose(Dmin)of acetylcholine causing a 35%decrease in total respiratory air conduction and specific respiratory system conductance(SGrs)before and after treatment in the two groups were compared.Results: After treatment, the fever subsidence time, the disappearance time of wheezes and wheezing sound and the remission time of dyspnea in the observation group were shorter than those in the control group,differences being significant(P<0.01).After treatment,the levels of CRP,TNF-α,WBC and NEUT in the two groups were decreased when compared with those before treatment(P < 0.05),and the above four indexes in the observation group were lower than those in the control group(P < 0.05).After treatment for one month and three months,the levels of FVC,FEV1,FEV1/FVC,MVV and MMF in the two groups were increased when compared with those before treatment respectively(P<0.05),the above five indexes in the observation group were higher than those in the control group(P < 0.05).The levels of PD35,Dmin and SGrs in the two groups were increased when compared with those before treatment(P < 0.05),and the above three indexes in the observation group were higher than those in the control group(P<0.05).Conclusion:The therapy of Yiqi Bushen Zhichuan tang combined with routine western medicine in treating children with asthma of spleen-kidney qi deficiency type can improve the clinical symptoms more rapidly,effectively reduce the injury of airway,improve the lung function,and further improve the curative effect.

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狄志敏.益气补肾止喘汤联合常规西药治疗小儿哮喘临床研究[J].新中医,2019,51(10):193-196

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  • 在线发布日期: 2019-10-11
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