To study the efficacy of Yiqi Yangyin Huoxue tang for diabetic nephropathy(DN)with qi-blood deficiency syndrome and its effect on renal tubular injury and glomerular sclerosis.Methods：Divided 162 cases of DN patients with qi-blood deficiency syndrome into the observation group and the control group randomly，with 81 cases in each group.Both groups were given basic treatment with routine control of blood glucose，blood pressure and lipid lowering，while the observation group was additionally given Yiqi Yangyin Huoxue tang；the two groups received continuous treatment for 6 months.Observed and compared the levels of fasting blood glucose(FBG)，glycosylated hemoglobin(HbA1c)，kidney functions[blood urea nitrogen(BUN)，urinary protein excretion rate(UPER)，urinary albumin/creatinine ratio(ACR)]，renal tubular damage indexes[(cystatin-C(Cys-C)，β2-microglobulin(β2-MG)，N-acetyl- β-D-glycosidase(NAG)]in the two groups before and after treatment，performed the renal biopsy，analyzed the glomerular sclerosis and compared the disease development of patients in the two groups by K-M risk map.Results：After treatment，the levels of FBG and HbA1c in the two groups were significantly lower than those before treatment(P ＜ 0.05)，but there was no significant difference being found in comparison between the two groups(P ＞ 0.05).After treatment，the BUN，UPER and ACR values of patients in the two groups were lower than those before treatment(P＜0.05)and the BUN，UAER，ACR values in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，the levels of Cys-C，β2-MG and NAG in the two groups were lower than those before treatment(P ＜ 0.05)and the levels of Cys-C，β2-MG and NAG in the observation group were lower than those in the control group(P ＜ 0.05).After 6 months of treatment，there was significant difference in pathological grading between the two groups by rank sum test(P ＜ 0.05)，The pathological improvement of the observation group was better than that of the control group.In terms of the risk of disease development，the risk of DN progression in the observation group was lower than that in the control group(P ＜ 0.05).Conclusion：On the basis of western medicine treatment，the additional application of Yiqi Yangyin Huoxue tang for DN with qi-blood deficiency syndrome can effectively improve the kidney functions，reduce the renal tubular injury and delay the disease development.