小金胶囊联合优甲乐治疗结节性甲状腺肿疗效评价及对甲状腺功能的影响
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R581.3

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Therapeutic Evaluation of Xiaojin Capsules Combined with Youjiale for Nodular Goiter and Its Effect on Thyroid Function
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    摘要:

    目的:观察小金胶囊联合优甲乐治疗结节性甲状腺肿的疗效评价及对甲状腺功能的影响。方法:将结节性甲状腺肿进行治疗患者100例,随机分为对照组与治疗组各50例,对照组常规给予优甲乐(左甲状腺素钠片)治疗,治疗组在对照组基础上加用小金胶囊联合治疗。观察治疗后结节最大径、甲状腺功能指标改变,包括高敏促甲状激素(sTSH)、游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4);比较治疗后2组患者总体疗效以及用药过程安全性情况。结果:治疗后,2组结节最大径均较之前缩小(P<0.05)。与对照组治疗后,治疗组结节最大径缩小更多,差异有统计学意义(P<0.05)。与对照组比较,治疗组治疗后sTSH水平降低幅度更小,差异有统计学意义(P<0.05)。2组治疗前后FT3、FT4指标比较,差异无统计学意义(P>0.05)。治疗组总有效率80%,对照组为56%,2组比较,差异有统计学意义(P<0.05)。对照组不良反应总发生率26%,治疗组为8%,2组比较,差异有统计学意义(P<0.05)。结论:优甲乐基础上给予小金胶囊联合治疗结节性甲状腺肿,可更加有效控制促甲状腺素的过度降低,减少结节直径,更有效保护患者甲状腺功能,且在更好的用药安全情况下增加治疗有效率。

    Abstract:

    To observe the therapeutic evaluation of Xiaojin capsules combined with Youjiale for nodular goiter and its effect on the thyroid function.Methods:A total of 100 cases of patients with nodular goiter were randomly divided into the control group and the treatment group,50 cases in each group.The control group was routinely treated with Youjiale(levothyroxine sodium tablets),and the treatment group was additionally treated with Xiaojin capsules based on the treatment of the control group.After treatment,the maximum diameters of nodules and the changes in indexes of the thyroid function including thyroid-stimulating hormone-sensitive(sTSH),free triiodothyronine(FT3)and free thyronine(FT4)were observed;the total curative effect and the medication safety in the two groups were compared.Results:After treatment,the maximum diameters of nodules in the two groups were decreased when compared with those before treatment(P < 0.05),and the decrease in the treatment group was larger than that in the control group,the difference being significant(P<0.05).After treatment,the decrease of the level of sTSH in the treatment group was smaller than that in the control group,the difference being significant(P<0.05).There was no significant difference being found in the comparison of FT3 and FT4 in the two groups before and after treatment(P>0.05).The total effective rate was 80%in the treatment group and 56%in the control group,the difference being significant(P<0.05).The total incidence of adverse reactions was 26%in the control group and 8%in the treatment group,the difference being significant(P< 0.05).Conclusion:The therapy of Xiaojin capsules based on Youjiale in treating nodular goiter can control the excessive decrease of thyrotropin more effectively,reduce the diameters of nodules,protect the thyroid function more effectively,and increase the effective rate of treatment with better medication safety.

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张辉,吕璟,干群.小金胶囊联合优甲乐治疗结节性甲状腺肿疗效评价及对甲状腺功能的影响[J].新中医,2019,51(10):137-139

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  • 在线发布日期: 2019-10-11
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