To investigate the effect of Fuzheng Huayu tablets combined with Entecavir on the improvement of liver fibrosis in patients with hepatitis B cirrhosis and its effect on levels of glucose(GLU)and lactate dehydrogenase(LDH)in ascites.Methods：A total of 278 patients with chronic hepatitis B with liver fibrosis were divided into the observation group and the control group according to the random number table method，139 cases in each group.The control group received Entecavir Dispersible tablets，and the observation group was additionally treated with Fuzheng Huayu tablets based on the treatment of the control group.Both groups were treated for 24 weeks.The levels of liver fibrosis， therapeutic effect，negative conversion rate of hepatitis b virus(HBV)and the levels GLU and LDH in ascites were compared between the two groups.Results：After treatment，the levels of the indexes of liver fibrosis including hyaluronic acid(HA)，procollagen Ⅲ(PCⅢ)，collagen Ⅳ(Ⅳ-C)，Laminin(LN)in the two groups were decreased(P ＜ 0.01)，and the level of liver fibrosis in the observation group was lower than that in the control group(P ＜ 0.01).After treatment，the total effective rate in the observation group was 95.68%，higher than that of 89.21%in the control group(P＜0.05).After 24 weeks of treatment，the HBsAg negative conversion rate，the HBeAg negative conversion rate and the HBV-DNA negative conversion rate were 74.82%，61.15%，78.42%respectively in the observation group，and 61.15%，48.20%，64.03%respectively in the control group，the difference being significant(P ＜ 0.05).After treatment，the levels of LDH and GLU in ascites in both groups were decreased(P＜0.01)，and the two levels in the observation group were lower than those in the control group(P＜0.01).Conclusion：The therapy of Fuzheng Huayu tablets combined with Entecavir is effective in the treatment of hepatitis B cirrhosis，and can reduce the levels of GLU and LDH in ascites.