To apply Yunnan Baiyao capsules combined with proton pump inhibitor for bleeding peptic ulcer，and to evaluate its clinical effect and safety.Methods：A total of 100 cases of patients with bleeding peptic ulcer were selected and divided into the control group and the study group according to the random number table method，50 cases in each group.The control group was treated with proton pump inhibitor based on routine treatment，and the study group was additionally treated with Yunnan Baiyao capsules based on the treatment of the control group.The hemostasis time，the blood transfusion volume，the disappearance time of gastrointestinal symptoms and the hospitalization time in the two groups were recorded；the scores of gastrointestinal symptoms before and after treatment were evaluated；the levels of hemoglobin(Hb)before and after treatment in the two groups were detected.Results：The significant effective rate was 72.00%in the study group，higher than that of 62.00%in the control group，the difference being significant(P ＜ 0.05).The hemostasis time，the blood transfusion volume，the disappearance time of gastrointestinal symptoms and the hospitalization time in the study group were less than those in the control group，differences being significant(P ＜ 0.05).Before treatment，there was no significant difference being found in the comparison of the scores of gastrointestinal symptoms and the levels of Hb in the two groups(P ＞0.05).After treatment，the scores of gastrointestinal symptoms in the two groups were decreased when compared with those before treatment，while the levels of Hb were increased；the score in the study group was lower than that in the control group，while the level of Hb was higher；differences being significant(P ＜ 0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions in the two groups(P＞0.05).Conclusion：The therapy of Yunnan Baiyao capsules combined with proton pump inhibitor in treating bleeding peptic ulcer has significant clinical effect，which can significantly shorten thehemostasistime，the disappearance timeof gastrointestinal symptomsand the hospitalization time and reduce the blood transfusion volume.