To observe the clinical effect of Jianpi Liqi tang combined with mosapride citrate capsules for functional dyspepsia.Methods：A total of 120 cases of patients with functional dyspepsia were selected as the study subjects，and were divided into the observation group and the control group according to the random number table method，60 cases in each group.The control group was treated with western medicine，and the observation group was additionally treated with Jianpi Liqi tang based on the treatment of the control group.Both groups were treated for four weeks.The clinical effect and the symptom scores as well as the scores of 36-Item Short Form Health Survey(SF-36)were compared before and after treatment in the two groups；the incidence of adverse reaction was recorded.Results：The total effective rate was 96.67%in the observation group and 75.00%in the control group，the difference being significant(P ＜ 0.05).After treatment，the scores of stuffiness and oppression or distending pain in the upper abdomen，poor appetite，belching and hiccup，as well as fatigue and asthenia in the two groups were decreased when compared with those before treatment(P ＜ 0.05)，and the decrease of the above four symptom scores in the observation group were more obvious than that in the control group(P＜0.05).After treatment，the scores of SF-36 in the two groups were increased when compared with those before treatment(P ＜ 0.05)，and the increase of the above score in the observation group were more obvious than that in the control group(P＜0.05).During the treatment，there was no adverse reaction in the two groups.Conclusion：The therapy of Jianpi Liqi tang combined with western medicine in treating functional dyspepsia has significant curative effect with high safety.