清金化痰汤联合西药治疗社区获得性肺炎临床研究
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R563.1

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Clinical Study on Qingjin Huatan Tang Combined with Western Medicine for Communityacquired pneumonia
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    摘要:

    目的:观察清金化痰汤联合西药治疗社区获得性肺炎的疗效。方法:选取175例痰热壅肺型社区获得性肺炎患者,按随机数字表法分为对照组85例和观察组90例,2组均给予盐酸左氧氟沙星注射液联合注射用阿莫西林克拉维酸钾治疗,观察组加用清金化痰汤,2组疗程均为1周。治疗前后评定2组患者的症状体征积分,检测血清白细胞介素-17(IL-17)、白细胞计数(WBC)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP) 水平。记录患者的发热消退时间、咳嗽停止时间、咯痰消退时间、啰音消失时间、住院时间。比较2组的临床疗效。结果:治疗后,对照组总有效率78.8%,观察组总有效率92.2%,2组比较,差异有统计学意义(P<0.05)。2组发热、咳嗽、咯痰、肺部啰音积分均低于治疗前(P<0.01),观察组发热、咯痰、肺部啰音积分均低于对照组(P<0.05,P<0.01)。2组WBC、TNF-α、hs-CRP和IL-17水平均较治疗前下降 (P<0.01),观察组4项指标值均低于对照组(P<0.01)。观察组发热消退时间、咳嗽停止时间、咯痰消退时间、啰音消失时间、住院时间均较对照组缩短(P<0.01)。结论:以清金化痰汤联合常规西药治疗社区获得性肺炎有更好的抗炎作用,可以提高临床疗效,更快速地改善症状,缩短患者的住院时间,节省住院费用。

    Abstract:

    To observe the curative effect of Qingjin Huatan tang combined with western medicine on community-acquired pneumonia.Methods:A total of 175 cases of patients with community-acquired pneumonia of phlegm-heat obstructing the lung type were divided into the control group and the observation group according to the random number table method,85 and 90 cases in each group respectively.Both groups were treated with levofloxacin hydrochloride injection combined with amoxicillin and clavulanate potassium for injection,and the observation group was additionally treated with Qingjin Huatan tang.Both groups were treated for one week.Before and after treatment,the scores of symptoms and signs in the two groups were evaluated, and the levels of interleukin-17(IL-17), white blood cell count(WBC), tumor necrosis factor-α (TNF-α)and hypersensitive c-reactive protein(hs-CRP)in serum were detected.The extinction time of fever, the stopping time of cough, the extinction time of expectoration, the disappearance time of rales and the hospitalization time were recorded.The clinical effect in the two groups was compared.Results:After treatment,the total effective rate was 78.8%in the control group and 92.2%in the observation group,the difference being significant(P<0.05).The scores of fever,cough,expectoration and rales in the lung in the two groups were lower than those before treatment(P<0.01),and the above scores in the observation group were lower than those in the control group(P<0.05,P<0.01).The levels of WBC,TNF-α,hs-CRP and IL-17 in the two groups were decreased when compared with those before treatment(P < 0.01),and the above four indexes in the observation group were lower than those in the control group,differences being significant(P < 0.01).The extinction time of fever,the stopping time of cough,the extinction time of expectoration,the disappearance time of rales and the hospitalization time in the observation group were shortened when compared with those in the control group,differences being significant(P< 0.01).Conclusion:The therapy of Qingjin Huatan tang combined with routine western medicine in treating community-acquired pneumonia has better anti-inflammatory effect,which can improve clinical effect, reduce symptoms more quickly, shorten hospitalization time and save hospitalization expenses.

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韩利峰.清金化痰汤联合西药治疗社区获得性肺炎临床研究[J].新中医,2019,51(10):60-63

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  • 在线发布日期: 2019-10-11
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