Objective：To observe the clinical effect of ziwuliuzhu nazi method combined with eyeshade for patients with insomnia with ventricular extrasystole of coronary heart disease.Methods：Divided 140 cases of patients into four groups randomly，35 cases in each group.The experiment group was treated with the ziwuliuzhu nazi method to open acupoints on time combined with Chinese medicine eyeshade for relieving uneasiness and protecting eyes；the acupoints selection in the control group 1 was exactly the same as that in the experiment group，but the acupuncture time was before or after the experiment group 1 to 4 days at the closing conditions of acupoints；the control group 2 was given the Chinese medicine eyeshade for relieving uneasiness and protecting eyes at 12∶00 every day； the control group 3 was treated with the combined method mentioned in the control group 1 and the control group 2.The treatment lasted for 30 days.Observed the electrocardiogram effect， ventricular premature beats， symptom scores before and after treatment， and Pittsburgh sleep quality index(PSQI)in each group.Results：The total effective rate of electrocardiogram was 91.43%in the experiment group and 68.57%in the control group 1，65.71%in the control group 2 and 71.43%in the control group 3，and the curative effect in the experiment group was better than that in other three control groups(P＜0.05).The total effective rate of the ventricular premature beats was 88.57%in the experiment group and 65.71%in the control group 1，62.86%in the control group 2 and 68.57%in the control group 3，and the curative effect in the experiment group was better than that in other control groups(P＜0.05).After treatment，the symptom scores of palpitations，chest distress，chest pain，shortness of breath and total scores of the patients in each group were decreased when compared with those before treatment，difference being significant(P＜0.05).After treatment，each symptom score and the total scores in the experiment group were lower than those in other control groups，difference being significant(P＜0.05).After treatment，the PSQI in each group was decreased when compared with those before treatment，difference being significant(P＜0.05).After treatment，compared the experiment group with other three control groups respectively，the PSQI in the experiment group was lower than that in each control group，difference being significant(P＜0.05).Conclusion：For patients with insomnia with ventricular extrasystole of coronary heart disease，the application of ziwuliuzhu nazi method to open acupoints on time combined with eyeshade for relieving uneasiness and protecting eyes can relieve palpitations and promote sleep in a simple，convenient，inexpensive and effective way.