火针四花穴治疗非小细胞肺癌化疗患者临床疗效及对Thl/Th2平衡的影响
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R734.2

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Observation on Curative Effect of Fire Needle at Sihua Point for Patients Undergoing Chemotherapy with Non-small Cell Lung Cancer and Its Effect on Th1/Th2 Balance
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    摘要:

    目的:观察火针四花穴治疗非小细胞肺癌化疗患者的临床疗效,并通过检测血清中干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)的含量探讨其可能机制。方法:将60例非小细胞肺癌患者随机分为2组各30例。对照组给予常规化疗(采用TP、GP、DP、AP方案进行化疗);观察组在常规化疗的基础上给予火针四花穴(膈俞、胆俞)治疗,治疗21天。治疗后,采用RECIST标准进行肿瘤客观指标评定,并分别在治疗前后检测患者血清IFN-γ、IL-4的含量。结果:治疗后,有效率(ORR)观察组20.0%,稳定率(OSD) 观察组73.3%,分别与对照组比较,差异均无统计学意义(P>0.05)。治疗后,对照组IFN-γ低于治疗前,而IL-4高于治疗前,差异均有统计学意义(P<0.05),治疗后,观察组IFN-γ高于治疗前,而IL-4低于治疗前,差异均有统计学意义(P<0.05),2组IFN-γ与IL-4呈负相关;治疗后,血清IFN-γ水平与RECIST评价呈正相关;治疗后,血清IL-4与RECIST评价不相关。结论:火针四花穴可能通过调节血清IFN-γ、IL-4含量调节Th1/Th2平衡逆转Th1向Th2漂移。

    Abstract:

    Objective:To observe the clinical effect of fire needle at Sihua point for patients undergoing chemotherapy with non-small cell lung cancer and investigate its possible mechanism by detecting the contents of interferon-γ(IFN-γ)and interleukin 4(IL-4)in serum.Methods:Divided 60 cases of patients with non-small cell lung cancer into two groups randomly,30 cases in each group.The control group was treated with routine chemotherapy in which TP,GP,DP and AP methods were used for chemotherapy,while the observation group was additionally given fire needle at Sihua point(Geshu and Danshu points)based on the routine chemotherapy.The treatment of the two groups lasted for 21 days.After treatment,the objective index of tumor was evaluated by RECIST criteria,and the contents of IFN-γ and IL-4 in serum were detected respectively before and after treatment.Results:After treatment,ORR was 20.0%and OSD was 73.3%in the observation group.There was no significant difference being found in the respective comparison of ORR and OSD between the two groups(P>0.05).After treatment,IFN-γ in the control group was lower than that before treatment while IL-4 was higher,differences being significant(P<0.05).After treatment,IFN-γ in the observation group was higher than that before treatment while IL-4 was lower,the difference being significant(P< 0.05).IFN-γ and IL-4 were negatively correlated with the counterparts respectively in the two groups.After treatment,the level of IFN-γ was positively correlated with the RECIST evaluation;IL-4 in serum was not correlated with RECIST evaluation.Conclusion:The therapy of fire needle at Sihua point possibly adjusts Th1/Th2 balance to reverse Th1 to drift to Th2 by regulating the contents of IFN-γ and IL-4 in serum.

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裴文娅,赵玮璇,刘琨,曾婧纯,阮经文,林国华.火针四花穴治疗非小细胞肺癌化疗患者临床疗效及对Thl/Th2平衡的影响[J].新中医,2018,50(12):211-214

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  • 在线发布日期: 2018-12-09
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