升血小板胶囊治疗消化道肿瘤化疗后血小板减少疗效观察
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R735; R558+.2

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Clinical Observation of Sheng Xuexiaoban Capsules for Thrombocytopenia after Chemotherapy in Gastrointestinal Tumor
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    摘要:

    目的:观察升血小板胶囊对消化道肿瘤患者化疗后血小板恢复的疗效。方法:将进行化疗的消化道肿瘤患者68例随机分为对照组和观察组各34例,对照组进行常规化疗后给予地塞米松治疗;观察组在对照组治疗的基础上加用升血小板胶囊治疗;3周后观察2组血小板恢复情况及2组患者治疗前后谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(Tb)的变化。结果:治疗后观察组血小板抑制程度0级、Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级患者占有率分别为44.12%、23.53%、14.71%、8.82%、8.82%,对照组分别为14.71%,11.76%、32.35%、23.53%、17.65%;观察组血小板抑制程度0、Ⅰ级患者多于对照组(P<0.05),Ⅱ、Ⅲ、Ⅳ级患者少于对照组(P<0.05)。治疗后观察组血小板值明显升高,与对照组比较,差异有统计学意义(P<0.05)。2组均无因药物毒副作用而停止治疗的患者,2组间治疗前后ALT、AST、ALP、Tb值比较,差异均无统计学意义(P>0.05)。结论:升血小板胶囊对消化道肿瘤患者化疗后血小板恢复具有较好疗效,且无明显肝毒性,值得临床推广应用。

    Abstract:

    Objective:To observe the curative effect of Sheng Xuexiaoban capsules for platelet recovery after chemotherapy in patients with gastrointestinal tumor.Methods:Divided 68 cases of patients with gastrointestinal tumor who underwent chemotherapy into the control group and the observation group,34 cases in each group.The control group was treated with dexamethasone after routine chemotherapy,while the observation group was additionally treated with Sheng Xuexiaoban capsules.After 3 weeks,observed the recovery of platelets in the two groups and the changes of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and total bilirubin(Tb)in the two groups before and after treatment.Results:After treatment,the occupancy rates of patients with platelet inhibition degree of grade 0,grade Ⅰ,gradeⅡ,gradeⅢ,and gradeⅣin the observation group were 44.12%,23.53%,14.71%,8.82%and 8.82%respectively and 14.71%,11.76%,32.35%、23.53%and 17.65%in the the control group respectively.The grade 0 and gradeⅠpatients with platelet inhibition degree in the observation group were more than those in the control group(P<0.05)and the gradeⅡ,Ⅲ andⅣ patients were less than those in the control group(P<0.05).After treatment,the platelet value in the observation group was significantly increased,compared with the control group,difference being significant(P<0.05).There were no patients who stopped the treatment because of toxic and side effects of drugs,and there were no significant difference being found in the comparisons of values of ALT,AST,ALP and Tb between the two groups before and after treatment(P>0.05).Conclusion:The application of Sheng Xuexiaoban capsules has good curative effect for platelets recovery after chemotherapy in patients with gastrointestinal tumor and has no obvious hepatotoxicity.It is worthy of clinical promotion and application.

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郑勇洪,侯凯哲.升血小板胶囊治疗消化道肿瘤化疗后血小板减少疗效观察[J].新中医,2018,50(12):184-186

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  • 在线发布日期: 2018-12-09
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