Objective：To observe the clinical effect of Shugan Bushen tang combined with cyproterone acetate tablets for polycystic ovary syndrome(PCOS).Methods：Divided 86 cases of patients with PCOS into two groups randomly，43 cases in each group.The control group was treated with cyproterone acetate tablets，while the observation group was treated with cyproterone acetate tablets combined with Shugan Bushen tang.The two groups received treatment for three courses，21 days being a course.Observed the volume of ovarian and endometrial thickness，detected the changes in levels of testosterone(T)，luteinizing hormone(LH)，follicle stimulating hormone(FSH)，monocyte chemoattractant protein-1(MCP-1)，glutathione peroxidase(GSH-Px)， advanced oxidation protein products(AOPP)， angiotensin II(AT-II)and adiponectin before and after treatment in the two groups，and recorded the ovulation and pregnancy of patients after treatment.Results：After treatment，endometrial thickness in the observation group was thicker than that in the control group，and the volume of ovarian was smaller than that in the control group，differences being significant(P＜0.05).After treatment，levels of T，LH and FSH in the observation group were lower than those in the control group，differences being significant(P＜0.05).After treatment，levels of GSH-Px and adiponectin in the observation group were higher than those in the control group，while levels of MCP-1，AOPP and AT-II in the observation group were lower than those in the control group，differences being significant(P＜0.05).After treatment，the ovulation rate and the pregnancy rate in the observation group were higher than those in the control group，but no significant difference was found in the comparisons of the ovulation rate and the pregnancy rate between the two groups(P＞0.05).Conclusion：The therapy of Shugan Bushen tang combined with cyproterone acetate tablets for PCOS can reduce the volume of ovarian，decrease the levels of sex hormone，MCP-1 and AT-II and relieve the oxidative stress reaction，so as to promote the ovulation.