Objective：To observe the clinical effect of Bazhen Yimu capsules combined with western medicine for qi and blood deficiency syndrome in the late menstrual period and effect on sex hormone levels.Methods：Selected 110 cases of patients who received diagnoses with qi and blood deficiency syndrome in the late menstrual period and randomly divided them into the treatment group and the control group according to random number table，55 cases in each group.The control group was treated with progynova pills and progesterone capsules，while the treatment group was additionally treated with Bazhen Yimu capsules.The treatment for both groups lasted for 3 courses，3 weeks as a course.Compared the symptom scores of qi and blood deficiency syndrome，sex hormone levels in serum[follicle stimulating hormone(FSH)，estradiol(E2)，leuteinizing hormone(LH)and prolactin(PRL)]before and after treatment and the clinical effect in the two groups，and recorded the incidence of adverse reactions in the two groups.Results：After treatment，the total effective rate was 90.91%in the treatment group，being higher than that of 74.55%in the control group，difference being significant(P＜0.05).The symptom scores of the qi and blood deficiency syndrome(dizziness and blurred vision，fatigue，lack of qi and no desire to speak，pale complexion)in two groups were decreased when compared with those before treatment(P＜0.01)；the previous four symptom scores in the treatment group were lower than those in the control group(P＜0.01).The levels of FSH，LH and PRL in serum in the two groups were decreased when compared with those before treatment；and the E2level was increased when compared with those before treatment，differences being significant(P＜0.01).The levels of FSH，LH and PRL in serum in the treatment group were lower than those in the control group；the level of E2was higher than that in the control group，differences being significant(P＜0.01).The incidence of adverse reactions was 16.36%in the treatment group and 21.82%in the control group，difference being insignificant(P＞0.05).Conclusion：Based on routine western medicine，the application of Bazhen Yimu capsules for qi and blood deficiency syndrome in the late menstrual period can effectively improve the symptoms of patients and promote the clinical effect.It is safer and its curative effect may be related to the regulation of the sex hormone levels in patients.