Objective：To observe the clinical effect of modified Dingjing tang combined with Luohuazizhu dispersible tablets for intermenstrual bleeding of liver depression and kidney deficiency type.Methods：Selected 142 cases of patients with intermenstrual bleeding of liver depression and kidney deficiency type admitted in our hospital，and divided them into the control group and the observation group according to the random number table method，71 cases in each group.The control group was treated with Luohuazizhu dispersible tablets，and the observation group was additionally treated with modified Dingjing tang based on the treatment of the control group.Compared and analyzed the clinical effect，and observed the changes in Chinese medicine syndromes，contents of luteinizing hormone(LH)and estradiol(E2)in serum as well as the endometrial thickness before and after treatment in the two groups.Results：The total effective rate was 87.32%in the observation group and 60.56%in the control group，the difference being significant(P＜0.05).There was no significant difference being found in the comparison of the score of Chinese medicine syndromes between the two groups before treatment(P＞0.05).After treatment，the score of Chinese medicine syndromes in the observation group was decreased when compared with that before treatment，lower than that after treatment in the control group，and the difference was statistically significant(P＜0.05).Compared the score of Chinese medicine syndromes in the control group before and after treatment，there was no significant difference(P＞0.05).No obvious changes in endometrial thickness and contents of LH and E2in serum before and after treatment were found，there being no significance in differences(P＞0.05).Conclusion：The therapy of modified Dingjing tang combined with Luohuazizhu dispersible tablets has significant therapeutic effect in treating intermenstrual bleeding of liver depression and kidney deficiency type，which can obviously improve the Chinese medicine syndromes of patients.