Objective：To observe the curative effect of Wenshen Bupi tang combined with western medicine for uremic peripheral neuropathy(UPN)with yang deficiency of spleen and kidney syndrome.Methods：Selected 110 cases of UPN patients with yang deficiency of spleen and kidney syndrome admitted in our hospital into the treatment group and the control group according to random number table method，55 cases in each group.The two groups were given routine interventions of hemodialysis combined with hemoperfusion.The control group additionally received mecobalamin tablets and trivitamin B injection for treatment，while the treatment group additionally received Wenshen Bupi tang based on the treatment of the control group.The two groups were treated for three months continuously.Compared the symptom scores of yang deficiency of spleen and kidney syndrome and sensory nerve conduction velocity(SCV)of lower limbs before and after treatment in the two groups， and analyzed the curative effect in the two groups.Results：After treatment， the total effective rate was 94.55%in the treatment group，higher than that of 80.00%in the control group，the difference being significant(P＜0.05).Scores of burnout and hypodynamia，deprivation and anorexia，shortness of breath and dislike of talking，soreness and weakness of waist and knees， abdominal distention， and tastelessness without thirsty feeling in the two groups were decreased when compared with those before treatment(P＜0.01)，and the above scores in the treatment group were lower than those in the control group(P＜0.01).The SCV of tibial nerve，sural nerve and peroneal nerve in the two groups was improved when compared with that before treatment respectively(P＜0.01)，and the improvement in the treatment group was more obvious than that in the control group(P＜0.01).Conclusion：Based on the routine interventions of hemodialysis combined with hemoperfusion，the therapy of Wenshen Bupi tang combined with western medicine for UPN with yang deficiency of spleen and kidney syndrome can obviously improve the clinical symptoms and increase the SCV of lower limbs of patients with accurate clinical effect.